3-(2-pyrrolidin-1-ylethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives as high affinity human 5-HT(1B/1D) ligands

Bioorg Med Chem Lett. 2004 Feb 9;14(3):727-9. doi: 10.1016/j.bmcl.2003.11.023.

Abstract

A series of 3-(2-pyrrolidin-1-ylethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives (2) has been prepared using parallel synthesis techniques, and their structure-activity relationships studied. High affinity human 5-HT(1B/1D) (h5-HT(1B/1D)) ligands have been identified.

MeSH terms

  • Humans
  • Indoles / chemistry*
  • Indoles / metabolism*
  • Ligands
  • Pyridines / chemistry*
  • Pyridines / metabolism*
  • Receptor, Serotonin, 5-HT1B / metabolism*
  • Structure-Activity Relationship

Substances

  • Indoles
  • Ligands
  • Pyridines
  • Receptor, Serotonin, 5-HT1B